SNP Research Center, Institute of Chemical and PhysicalResearch (RIKEN),
Institute of Medical Science, University of Tokyo,4-6-1 Shirokanedai, Minato,
Tokyo 108-8639, Japan
Institute of Reumatology, Tokyo Women's Medical University,10-22 Kawada-cho,
Shinjuku-ku, Tokyo 162-0054, Japan
The most challenging strategy for analyzing genome-wide polymorphisms and/or expression profiles is to solve multi-factor causal-relationship simultaneously. As the first step, we propose a framework of association study using maximum likelihood method that simultaneously handles genetic polymorphisms and epi-genetic information, e.g. environmental factors. We evaluate the theory by applying it to genotyped data of myocardial infarction (MI) patients.