CaMPDB: a Resource for Calpain and Modulatory Proteolysis
David duVerle [1](dave@kuicr.kyoto-u.ac.jp)
Ichigaku Takigawa [1](takigawa@kuicr.kyoto-u.ac.jp)
Yasuko Ono [2](ono-ys@igakuken.or.jp)
Hiroyuki Sorimachi [2](sorimachi-hr@igakuken.or.jp)
H. Mamitsuka [1](mami@kuicr.kyoto-u.ac.jp)
[1] Bioinformatics Center, Kyoto University, Gokasho, Uji
611-0011, Japan
[2] Calpain Project, Rinshoken, Tokyo 156-8506, Japan
Abstract
While the importance of modulatory proteolysis in research has steadily increased,
knowledge on this process has remained largely disorganized,
with the nature and role of entities composing modulatory proteolysis still uncertain.
We built CaMPDB, a resource on modulatory proteolysis, with a focus on
calpain, a well-studied intracellular protease which regulates
substrate functions by proteolytic processing.
CaMPDB contains sequences of calpains, substrates and inhibitors as well
as substrate cleavage sites, collected from the literature.
Some cleavage efficiencies were evaluated by biochemical experiments
and a cleavage site prediction tool is provided to assist biologists in
understanding calpain-mediated cellular processes.
CaMPDB is freely accessible at http://calpain.org
Japanese Society for Bioinformatics