東京農工大学ゲノム科学人材育成国際セミナー

 

 東京農工大学では平成23年度より、ゲノミクス、プロテオミクス、メタボロミクス、バイオインフォマティクス領域における人材育成プログラムを展開してきました。

 今回、中国の北京ゲノム研究所(BGI)において世界でトップレベルのゲノミクスの研究を推進しNature、Science等のトップジャーナルに多数投稿している研究者をお招きしてセミナーを行うことになりました。ワールドクラスの研究者の講演を聴講する絶好の機会と考えますので、ご興味のある方はぜひご参加ください。セミナーは誰でも参加可能です。

 

日時: 2012(平成24)年9月26日(水)13:30~16:30
場所: 東京農工大学農学部, 第2講義棟視聴覚教室
受講対象者: 誰でも参加できます。参加費用は無料です。
(講演は英語で行われます。学外からの参加希望者は、予めご連絡ください。)


講演者及びタイトル
Xiaodong FANG, Bioinformaican, Leader of plant and animal genome
group, BGI-shenzhen, China
Title: Genome assembly and functional analysis of oyster

Likai MAO, Scientist of Plants & Animals Trans-omics, BGI, Shenzhen, China
Title: The power of phylogeny analysis based on transcriptome data

Guangliang YIN, Scientist of Cancer Research of Human Transomics,
Science&Techonology Division, BGI, Shenzhen, China
Title: Epigenomics and Transcriptomics Studies in Cancer Researches

本セミナーの問合せ先kishii@cc.tuat.ac.jp
(石井一夫、東京農工大学農学系ゲノム科学人材育成プログラム)
http://genome.lab.tuat.ac.jp/~genome/

参考サイト
BGI http://www.genomics.cn/en/index


 

講演要旨

 


Genome assembly and functional analysis of oyster
Xiaodong FANG, Bioinformaican, Leader of plant and animal genome
group, BGI, Shenzhen, China

Abstract:
The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. We report the sequencing and assembly of the oyster genome using short-reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response, and proteome of shell. The oyster genome is highly polymorphic and rich in repetitive sequences, with some transposable elements still actively shaping variation. Transcriptome studies reveal an extensive set of genes responding to environmental stress. Expansion of heat shock protein 70 and of inhibitors of apoptosis is likely central to the oyster’s adaptation to sessile life in the highly stressful intertidal zone. Our analyses also show shell formation in molluscs is more complex than currently understood and involves extensive participation of cells and their exosomes. The oyster genome sequence fills a void in our understanding of the Lophotrochozoa.

 


The power of phylogeny analysis based on transcriptome data
Likai MAO, Scientist of Plants & Animals Trans-omics, BGI, Shenzhen, China

Abstract:
Figuring out evolutionary relationship has been playing important roles in varieties of biological fields. Evolutionary scientists have been building phylogenetic trees using a handful of genetic sequences. However, this often produced controversial trees with low support especially in deep nodes. Next-generation sequencing has brought great hope to accomplish this daunting task. However, it needs a big-enough budget to perform whole-genome sequencing. In contrast, transcriptome sequencing produces comparable amount of gene data with much lower expenses which are affordable for most researchers. In this talk, we will present some work, including ourselves', of creating robust phylogenies revealing deep relationships in various species, showing the power of phylogeny analysis based on transcriptome data.


Epigenomics and Transcriptomics Studies in Cancer Researches
Guangliang YIN, Scientist of Cancer Research of Human Transomics, Science&Techonology Division, BGI, Shenzhen, China

Abstract:
Next generation sequencing (NGS) provides promising means to study human personal genomes and human diseases, like cancers. Although cancers are widely recognized to be an accumulative process with somatic mutations, the epigenetics alterations in last decades are becoming clear that has an important role involved in various stages of cancer development. In addition, dysregulations of gene expression as well as structural variations in cancer cells were identified to be as biomarkers for diagnosing and classification of subtypes of cancers. Many experimental approaches and analytical tools were developed for epigenetics studies and transcriptome studies. BGI, as a leading genomics institute in multidisciplines research in world, is also focusing on these fields in cancer studies. We believed that epigenomics and transcriptomics analyses in cancer studies are indispensable for not only tumorigenesis studies, but personalized treatments for cancer patients by using NGS as well.