Conservation of Protein Interaction Network in Evolution

Jong Park (
Dan Bolser (

MRC-DUNN Human Nutrition Unit, Hills Road, Cambirdge, CB22XY, England, UK


A functional analysis of protein fold interaction suggested that structural fold familieshave gradually acquired more diverse interacting partners while maintaining central biochemical interactions and functions. This means thatthe protein interaction network (map) maintains its robust architecture due to the functional constraints associated with the interactions.

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Japanese Society for Bioinformatics