Intercellular Communications Induced by Random Fluctuations

Tianshou Zhou[1] (
Luonan Chen[2] (
Ruiqi Wang[2] (
Kazuyuki Aihara[3] (

[1]Tsinghua University, Beijing 100084, China
[2]Osaka Sangyo University, Daito, Osaka 574-8530, Japan
[3]The University of Tokyo, Bunkyo-Ku, Tokyo 113-8656, Japan


This paper investigates a general coupled noisy system for a cell-cell communication in a multi-cell system. The main conclusion is that appropriate noise intensity and coupling strength are capable of driving the coupled system to synchrony, which may be exploited by biological organisms to actively facilitate mutual communication. A multi-cell system with a synthetic gene network with both noises and delays is adopted to demonstrate the effect of noises on cellular communication.

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Japanese Society for Bioinformatics