Genome informatics is a rich and rapidly expanding area which covers such diverse topics as construction and use of biological databases, analysis of biological sequences and related data, macromolecular structure modeling and prediction, computer aided drug design, systems biology, and network biology, among others. The Fifteenth International Conference on Genome Informatics (GIW 2004) was held at Yokohama Pacifico in Yokohama, Japan, during December 13-15, 2004. The GIW conference series provides an international forum where researchers and engineers, who work on genome informatics and related topics, meet to discuss and exchange experiences on the latest advances in this area.
  Genome Informatics Vol. 15, No. 2 comprises full papers presented at the GIW 2004. The program committee of GIW 2004 received a record number of 64 full paper submissions, of which 29 papers were accepted for oral presentation at the conference and have been included in this issue. Each paper was reviewed by at least two members of the Program Committee. We thank the program committee members for their support of GIW 2004 and rigorous reviews of the submitted papers.
  GIW 2004 has invited three keynote speakers: Dr. Kunihiko Kaneko of University of Tokyo, Dr. Alessandro Sette of La Jolla Institute for Allergy and Immunology, and Dr. Ron Shamir of Tel Aviv University. The abstracts of the keynote talks are also included in this issue. The electronic version of Genome Informatics Vol. 15, No. 2 will be available from the Japanese Society for Bioinformatics web page ( The articles published in this issue will be indexed by Medline.

Tatsuya Akutsu
Vladimir Brusic
GIW 2004 Program Committee Co-Chairs

GIW 2004 was supported by the Grant-in-Aid for Scientific Research on Priority Areas (C) “Genome Information Science” from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and Japanese Society for Bioinformatics (JSBi). GIW 2004 was organized with the help of Bioinformatics Center, Institute for Chemical Research, Kyoto University and Human Genome Center, Institute of Medical Science, University of Tokyo. Special thanks are due to the GIW 2004 secretariat members for their excellent work, especially, Hideo Bannai, Ayako Brecht, Seiya Imoto, Kaori Samuraki, Asako Suzuki, and Mizuho Wada.