This issue of Genome Informatics contains papers presented at theSixteenth International Conference on Genome Informatics (GIW 2005) held in Yokohama, Japan from December 19th to 21st, 2005.The GIW series provides an international forum fordisseminating the latest development and application of advancedcomputational methods for biological problems.Its scope includes all topics in bioinformatics and systems biology,including analyzing biological sequences, employing fast algorithms forprotein-protein docking, generating gene regulatory networks frommicroarray data and graph mining for structured biological data.
The program committee of GIW 2005 received 49 submissions in total.Each submitted paper was considered by at least two members of theprogram committee.Based on their reports, 26 papers were accepted for presentation at theconference.These 26 papers appear in this book and are indexed in Medline.In addtion, this book contains abstracts from the three invited speakers:Pierre Baldi of the University of California at Irvine, Gunnar von Heijneof Stockholm University and Shigeru Kondo of Nagoya University.The electronic versions of all these papers in this issue are freelyavailable from the website of the Japanese Society forBioinformatics (JSBi)(

Reinhart Heinrich
Hiroshi Mamitsuka
GIW 2005 Program Committee Co-Chairs


First of all, we would like to thank the authors for their effort inpreparing their manuscripts.We also appreciate the time invested by the program committee membersin the reviewing process.We further acknowledge the assistance from the local organizingcommittee members for arranging the conference venue.Special thanks are due to the conference editorial staff for theirexcellent work, especially, Emi Ikeda, Hitoshi Koyano, Ayumu Saito,Ayako Brecht, Asako Suzuki, Masao Nagasaki and other Miyano laboratory members.
Finally, GIW 2005 would not have been possible without the support andsponsorship of the Grant-in-Aid for Scientific Research onPriority Areas ``Systems Genomics Towards System-Level Understanding of Life'' (MEXT, Japan), JSBi,the Bioinformatics Center (Kyoto University) and the Human Genome Center (University of Tokyo).