Prediction of Promoter Expression Specificity by Conserved Sequence Patterns

Wataru Fujibuchi (
Minoru Kanehisa (

Institute for Chemical Research, Kyoto University
Uji, Kyoto 611, Japan


We present here a prediction method for expression specificities of promoters by observing the appearance of conserved sequence patterns in a group of promoters, such as liver, brain, and house-keeping. Related promoters in the same group were compiled from EPD [1] database and an index to represent the group specificity of each pattern was calculated. Each promoter was examined for its specificity by the collection of these indices constructed from the rest of the promoters in our dataset. Currently, our system could discriminate 50 % of human liver promoters with 11 % false positive rate. The distribution profile of scores also suggested that the liver promoter group may be divided into two or more subgroups.