Establishment and Management of Transcription Factor Database TFDB

T. Okazaki [1] (
M. Kaizawa [2] (
H. Mizushima [1] (

[1] Bioinformatics Section, Cancer Information and Epidemiology Division,
National Cancer Center Research Institute,
5-1-1 Tsukiji Chuo-ku, Tokyo 104, Japan
[2] Systems Science Department,
Mitsubishi Research Institute, Inc.,
2-3-6 Otemachi Chiyoda-ku, Tokyo 100, Japan


D. Gohsh of National Center for Biotechnology Information (NCBI), National Library of Medicine, National Institute of Health originally maintained 'TFD (Transcription Factor Database)' from 1990. As NCBI stopped its maintenance since 1993, we started a new database, TFDB (Transcription Factor DataBase), to take over some parts of the database focusing to the DNA binding sequence data. To update the database with recent data, we developed system which search literature database exhaustively and extract related information from the abstracts of collected articles. We also developed mail server to search target sequence of transcription factor using this database.