Application of Data Mining to Genetic Linkage Analysis

Nobutaka Mitsuhashi [1] (
Haretsugu Hishigaki [1] [2] (
Toshihisa Takagi [1] (

[1] Human Genome Center
Institute of Medical Science, The University of Tokyo,
4-6-1 Shirokanedai, Minatoku, Tokyo 108 Japan
[2] Otsuka GEN Research Institute, OTSUKA Pharmaceutical Co., Ltd.,
463-10 Kagasuno, Kawauchi-cho, Tokushima 771-01 Japan


Genetic linkage analysis tools, which are used to determine the genetic distance and order among genetic markers, take too much computational cost. To improve the efficiency, we are investigating the applicability of data mining to linkage analysis from both statistical and practical aspects. In this paper, we report the results of the investigation and discuss the problems.