A System for Identifying Genetic Networks from Gene Expression Patterns Produced by Gene Disruptions and Overexpressions

Tatsuya Akutsu[1] (takutsu@ims.u-tokyo.ac.jp)
Satoru Kuhara[2] (kuhara@grt.kyushu-u.ac.jp)
Osamu Maruyama[1] (maruyama@ims.u-tokyo.ac.jp)
Satoru Miyano[1] (miyano@ims.u-tokyo.ac.jp)

[1] Human Genome Center, Institute of Medical Science, University of Tokyo
4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
[2] Graduate School of Genetic Resources Technology, Kyushu University
6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan


A hot research topic in genomics is to analyze the interactions between genes by systematic gene disruptions and gene overexpressions. Based on a boolean network model without time delay, we have been investigating efficient strategies for identifying a genetic network by multiple gene disruptions and overexpressions. This paper first shows the relationship between our boolean network model without time delay and the standard synchronous boolean network model. Then we present a simulator of boolean networks without time delay for multiple gene disruptions and gene overexpressions, which includes a genetic network identifier with a graphic interface that generates instructions for experiments of gene disruptions and overexpressions.

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Japanese Society for Bioinformatics