Tracing Synergetic Behavior of the QTLs Affecting Oral Glucose Tolerance in the OLETF Rat

Akihiro Nakaya[1] (
Haretugu Hishigaki[2] (
Shinichi Morishita[1] (

[1] Institute of Medical Science, The University of Tokyo
4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
[2] Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd.
463-10 Kagasuno, Kawauchi-cho, Tokushima 771-0192, Japan


The synergetic effects of multiple marker loci regarding quantitative traits such as blood glucose level have attracted interest. In the OLETF model rat of non-insulin dependent diabetes mellitus (NIDDM), our previous study focusing on the effects of multiple genetic factors has found significant marker combinations with respect to oral glucose tolerance (OGT) at 60 minutes after oral administration. Besides the interaction among markers at a particular time point, their correlated behavior in a time series is another interest. Based on the previous results, in this paper, we report the behavior of markers in a time series by using a series of measurements of OGT.

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Japanese Society for Bioinformatics