The Role of IP3R Clustering in Ca2+ Signaling

Alexander Skupin (
Martin Falcke (

Max-Delbrück-Center for Molecular Medince, Departement of Mathematical Cell Physiology, Robert-Rössle-Str. 10, 13125 Berlin, Germany.


Ca2+ is the most important second messenger controlling a variety of intracellular processes by oscillations of the cytosolic Ca2+ concentration. These oscillations occur by Ca2+ release from the endoplasmic reticulum (ER) into the cytosol through channels and the re-uptake of Ca2+ into the ER by pumps. A common channel type present in many cell types is the inositol trisphosphate receptor (IP3R), which is activated by IP3 and Ca2+ itself leading to Ca2+ induced Ca2+ release (CICR). We have shown in an experimental study [15], that Ca2+ oscillations are sequences of random spikes that occur by wave nucleation. We use here our recently developed model for Ca2+ dynamics in 3 dimension to illuminate the role of IP3R clustering within spatial extended systems.

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Japanese Society for Bioinformatics